Oral lyophylizate formulation of desmopressin: superior pharmacodynamics compared to tablet due to low food interaction.

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TitleOral lyophylizate formulation of desmopressin: superior pharmacodynamics compared to tablet due to low food interaction.
Publication TypeJournal Article
Year of Publication2011
AuthorsDe Guchtenaere, A, Van Herzeele, C, Raes, A, Dehoorne, J, Hoebeke, P, Van Laecke, E, Vande Walle, J
JournalJ Urol
Volume185
Issue6
Pagination2308-13
Date Published2011 Jun
ISSN1527-3792
KeywordsAntidiuretic Agents, Chemistry, Pharmaceutical, Child, Deamino Arginine Vasopressin, Female, Food-Drug Interactions, Humans, Male, Nocturnal Enuresis, Tablets, Therapeutic Equivalency
Abstract

PURPOSE: Desmopressin is a standard treatment for monosymptomatic nocturnal enuresis. Different formulations are promoted as bioequivalent, although these claims are not supported by comparative pharmacodynamic data in children. Food interaction is known to influence the bioavailability of desmopressin. We compared the pharmacodynamics of the 2 most frequently used desmopressin formulations, tablet and lyophilizate, with a standardized meal, allowing extrapolation to clinical reality, where the interval between evening meal and medication intake is limited for school-age children. We hypothesized there would be a faster pharmacodynamic response, and greater concentrating and antidiuretic activity for the fast dissolving (melt) formulation compared to the tablet with simultaneous food intake. MATERIALS AND METHODS: Two tests were performed on separate days in identical standardized conditions, starting with a 15 ml/kg water load. After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test). Diuresis rate and urinary osmolality were measured hourly. Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained. RESULTS: In the early response phase more than 25% of patients had a higher diuresis rate with tablet vs melt formulation, reaching statistical significance in the plateau phase (urine collected at hours 3 to 5, p <0.02) and in duration of action (urine collected at hours 5 to 8, p <0.005). For desmopressin melt smaller standard deviations in diuresis rate were remarkable. Concentrating capacity demonstrated no significant differences between formulations in the early response phase, in contrast to the plateau phase (p <0.036) and duration of action (p <0.001). CONCLUSIONS: With meal combination desmopressin melt formulation has a superior pharmacodynamic profile to tablet, making it more suitable for the younger age group with a limited interval between meal and drug administration.

DOI10.1016/j.juro.2011.02.039
Alternate JournalJ. Urol.
Citation Key117
PubMed ID21511277

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